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Annihilus () is a supervillain appearing in American comic books published by Marvel Comics, primarily as an adversary to the Fantastic Four. The character debuted in Fantastic Four Annual #6, which was published in November 1968. Annihilus was created by writer Stan Lee and artist Jack Kirby, and was notably featured in the "Annihilation" event.
Annihilus has at various times been the ruler of the Negative Zone, controlling its inhabitants via his powerful Cosmic Control Rod. He first encountered the Fantastic Four after Reed Richards discovered how to travel to the Negative Zone from Earth. Over the years he clashed with the Fantastic Four on many occasions, often with the group foiling his plans to invade Earth. He is often the partner of Blastaar, who started out as a rival to Annihilus' rule of the Negative Zone before becoming allies.
Annihilus has appeared in a number of Marvel media, including several Fantastic Four shows, The Super Hero Squad Show, The Avengers: Earth's Mightiest Heroes, Hulk and the Agents of S.M.A.S.H. and Ultimate Spider-Man. In 2009, Annihilus was ranked as IGN's 94th Greatest Comic Book Villain of All Time.